|Characteristic||Values indicating a more favorable prognosis|
|Age at diagnosis||< 2 years old|
|Other existing conditions||Diagnosis of Noonan's Syndrome|
Without treatment, the survival of children with JMML is approximately 5%.
Only Hematopoietic Stem Cell Transplantation (HSCT), commonly referred to as a bone marrow or (umbilical) cord blood transplant, has been shown to be successful in curing a child of JMML; with HSCT, recent research studies have found the survival rate to be approximately 50%.
Relapse is a significant risk after HSCT for children with JMML; it is the greatest cause of death in JMML children who have had stem cell transplants. Relapse rate has been recorded as high as 50%. Many children have been brought into remission after a second stem cell transplant, so this should always be considered seriously as a treatment possibility after relapse.If you need help with some of the medical terms included in these pages, please use the NIH Medical Glossary.