Improved outcomes associated with stem cell transplantation for children with serious chronic leukemia

23 Jul 2015 10:12 AM | Anonymous


Source: Childrens Hospital Los Angeles


Researchers in the Division of Hematology, Oncology and Blood & Marrow

Transplantation at Children's Hospital Los Angeles have shown greatly 

improved outcomes in using stem cell transplantation to treat patients with

a serious..but very rare form of chronic blood cancer called juvenile

myelomonocytic leukemia (JMML).

Allogeneic hematopoietic stem cell transplantation (HSCT) involves the transplantation of stem cells from a donor, which may be derived from bone marrow, peripheral blood or umbilical cord blood. The recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. It is the only reported cure for JMML; however best outcomes of the therapy have shown only that half of patients can be cured from their disease. According to the researchers, there is currently no standard conditioning regimen for children with JMML undergoing HSCT.

The CHLA study, led by Hisham Abdel-Azim, MD, looked at children with JMML who underwent HSCT at Children's Hospital Los Angeles. All of the patients were alive and in clinical remission.

"The lack of transplant-related mortality in the group of children we studied at the Children's Center for Cancer and Blood Diseases at CHLA suggests that BUMEL (Intravenous Busulfan and Melphalan) may represent a successful HSCT high-dose chemotherapy regimen," said Abdel-Azim. "It is also possible that administering conventional dose chemotherapy, before HSCT, to patients with more progressive disease may have contributed to the improved outcomes."

He added that a follow up clinical trial is warranted to confirm these promising findings, which are published in the July 23, 2015, issue of the journal Blood.

Story Source:

The above post is reprinted from materials provided by Childrens Hospital Los AngelesNote: Materials may be edited for content and length.

Journal Reference:

  1. Q. Zhao, K. M. Mahadeo, N. Kapoor, H. Abdel-Azim. Improved outcomes associated with hematopoietic stem cell transplantation for patients with juvenile myelomonocytic leukemiaBlood, 2015; 126 (4): 561 DOI: 10.1182/blood-2015-05-644161



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